A Tumor Cell-Specific Nuclear Targeting Signal within Chicken Anemia Virus VP3/Apoptin
نویسندگان
چکیده
منابع مشابه
Chicken anemia virus.
Chicken anemia virus is commonly found in commercially produced chickens and has a worldwide distribution. It is difficult to inactivate thermally or with common disinfectants, which limits the utility of normal sanitization practices. The virus is important because of the disease it produces following transovarian transmission and because of its potential for inducing immunosuppression alone o...
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متن کاملApoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells.
Tumor cell-specific activity of chicken anemia virus viral protein 3 (VP3 or apoptin) is believed to be dependent on its ability to localize in the nucleus of transformed but not of primary or nontransformed cells. The present study characterizes the signals responsible for the novel nucleocytoplasmic trafficking properties of VP3 using two isogenic tumor/nontumor cell pairs. In addition to the...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2005
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.79.2.1339-1341.2005